Ro 90-7501

Product Specifications

CAS Number

293762-45-5

Target

ATM/ATR|||Gamma-secretase|||Beta Amyloid|||Phosphatase|||Apoptosis

Related Pathways

Apoptosis|||Metabolism|||Stem Cells|||DNA Damage/DNA Repair|||Proteases/Proteasome|||Neuroscience|||PI3K/Akt/mTOR signaling

Purity

0.998

Bioactivity

Ro 90-7501 is an amyloid ?42 (A?42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.