Polygalacic acid

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

Product Specifications

CAS Number

[22338-71-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE) ; MMP

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/polygalacic-acid.html

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]([C@@]1([H])[C@]2(C[C@H](O)[C@@H]3O)C)(CC[C@@]2([H])[C@]3(C)CO)[C@@](C4=CC1)(C[C@@H](O)[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)C

Molecular Formula

C30H48O6

Molecular Weight

504.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252.|[2]Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23 (2) :149-55.