GNE-6640
GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].
Product Specifications
CAS Number
2009273-67-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-6640.html
Purity
99.91
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
Molecular Formula
C20H18N4O
Molecular Weight
330.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550 (7677) :534-538.|[2]Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85 (4) :627-639.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TM42710 100 Reactions
Cryptococcus neoformans TaqMan Probe/Primer and Control Set
Sign In for Pricing
View Details 
![Carboxypeptidase M (CPM) Mouse Monoclonal Antibody [Clone ID: OTI1C10]](https://cdn.genprice.uk/products/937/68dd18b9061270361e90805d/imageurl/cf807318.webp)
CF807318 100 µg
Carboxypeptidase M (CPM) Mouse Monoclonal Antibody [Clone ID: OTI1C10]
Sign In for Pricing
View Details 
BNCB2761-500 1x 500 µL
CD40 Ligand / CD154 / TRAP1 (Activation Marker of T-Lymphocytes) (CD40LG/2761), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
