ROCK2-IN-8
ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC50 of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation[1].
Product Specifications
CAS Number
681173-76-2
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rock2-in-8.html
Purity
99.85
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(C1OC2=C(OC1)C=CC=C2)NC3=NC(C4=CC=NC=C4)=CS3
Molecular Formula
C17H13N3O3S
Molecular Weight
339.37
References & Citations
[1]Feng Y, et al. Discovery of substituted 4- (pyrazol-4-yl) -phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51 (21) :6642-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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