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Eliglustat (hemitartrate)

Eliglustat hemitartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

Product Specifications

CAS Number

[928659-70-5]

Product Name Alternative

Genz-112638; Eliglustat tartrate

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Eliglustat-hemitartrate.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

CCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O.CCCCCCCC(N[C@H](CN4CCCC4)[C@@H](C5=CC=C(OCCO6)C6=C5)O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O

Molecular Formula

C50H78N4O14

Molecular Weight

959.17

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91 (3) :259-67.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

BioRxiv. 2021 Feb 2.|Cancer Discov. 2023 Feb 6;13 (2) :454-473.|Immunity. 2021 Jan 12;54 (1) :132-150.e9.|Int J Biol Macromol. 2024 Dec 2:285:138303.|Leiden University. 2022 Jun 15.|PLoS One. 2021 Oct 25;16 (10) :e0247211.|Stem Cells Transl Med. 2021 Jul;10 (7) :1081-1094.|Cell Death Dis. 2021 Oct 6;12 (10) :911.|EMBO J. 2023 Jan 16;42 (2) :e110553.|Nat Commun. 2020 Aug 27;11 (1) :4279.|Nat Commun. 2024 Aug 14;15 (1) :6970.|PLoS Biol. 2025 Sep 11;23 (9) :e3003362.|Sci Adv. 2025 Oct 31;11 (44) :eaea1212.

Available Sizes

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