ALK-IN-21

ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALKWT, ALKL1196M and ALKG1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC50 values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma[1].

Product Specifications

CAS Number

[2901889-01-6]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK)

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alk-in-21.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(NC2=NC(NC3=C(C=CC=C3)S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)C(CSC(N5CCS(=O)(CC5)=O)=S)=O)OC(C)C

Molecular Formula

C35H45ClN6O6S4

Molecular Weight

809.48

References & Citations

[1]Xinyue Wang, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors. Bioorg Med Chem. 2022 Jul 15;66:116794.