(Thr4, Gly7) -Oxytocin

(Thr4, Gly7) -Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4, Gly7) -Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].

Product Specifications

CAS Number

[60786-59-6]

UNSPSC

12352209

Hazard Statement

H332

Target

Oxytocin Receptor; Potassium Channel

Type

Peptides

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/thr4-gly7-oxytocin.html

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N1)=O)N)C(NCC(N[C@@H](CC(C)C)C(NCC(N)=O)=O)=O)=O)=O)CC(N)=O)=O)([H])[C@H](O)C)=O)([H])[C@@H](C)CC)[C@@H]1CC2=CC=C(C=C2)O

Molecular Formula

C39H61N11O12S2

Molecular Weight

940.10

Precautions

H332

References & Citations

[1]Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46 (5) :1045-1056. |[2]Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31 (5) :2402-2415. |[3]M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69 (2) :105-11.