Acid Ceramidase-IN-2

Acid Ceramidase-IN-2 (compound 1) is an acid ceramidase inhibitor with potentially antiproliferative and cytostatic activities. Moreover, human acid ceramidase is overexpressed in prostate cancer cells, indicating potential anti-tumor effect of Acid Ceramidase-IN-2. And Acid Ceramidase-IN-2 hydrolysis can be inhibited by 3 a-ketoamides GT85, GT98 and GT99 inhibits in vitro[1].

Product Specifications

CAS Number

[1005497-03-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/acid-ceramidase-in-2.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)CCOC1=CC=C(C=CC(O2)=O)C2=C1)=O

Molecular Formula

C30H47NO6

Molecular Weight

517.70

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bedia C, et al. Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem. 2007 Apr 16;8 (6) :642-8.