UNC569

UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC569 also inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research[1][2]

Product Specifications

CAS Number

[1350547-65-7]

Product Name Alternative

Tyrphostin NT157

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TAM Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc569.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C2=NN(C[C@H]3CC[C@H](N)CC3)C4=NC(NCCCC)=NC=C42)C=C1

Molecular Formula

C22H29FN6

Molecular Weight

396.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Sandra Christoph, et al. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov;12 (11) :2367-77.|[2]Jing Liu, et al. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett. 2012 Feb 9;3 (2) :129-134.