Necrostatin
Necroptosis inhibitor
Product Specifications
Background
Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
Product Name Alternative
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.01
Format
Light Yellow Solid
Solubility
Soluble to 15 mM in ethanol, and to 30 mM in DMSO
Molecular Formula
C13H13N3OS
Molecular Weight
259.33
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573.
2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.
3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.
CAS Number
4311-88-0
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