L-Leucine-13C

L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Product Specifications

CAS Number

[74292-94-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; mTOR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-leucine-13c.html

Concentration

10mM

Purity

99.4

Solubility

H2O : 5mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)C[C@H](N)[13C](O)=O

Molecular Formula

C5 13CH13NO2

Molecular Weight

132.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9 (10) :e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) . 2012 Aug 22;9 (1) :77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61 (2) :409-17.