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GS-9901

GS-9901 is a highly selective and orally active PI3Kδ inhibitor with an IC50 of 1 nM. GS-9901 has ≥100 fold selectivity for PI3Kα (IC50 of 750 nM), PI3Kβ (IC50 of 100 nM) and PI3Kγ (IC50 of 190 nM) . GS-9901 can be used for the study of rheumatoid arthritis[1].

Product Specifications

CAS Number

1640247-87-5

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gs-9901.html

Purity

99.97

Solubility

DMSO : ≥ 250 mg/mL

Smiles

NC1=NC(N)=NC(N[C@H](C2CC2)C(N3C4=CN=CC=C4)=NC5=C(F)C=CC(Cl)=C5C3=O)=C1C#N

Molecular Formula

C22H17ClFN9O

Molecular Weight

477.88

References & Citations

[1]Patel L, et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 2016 Oct 13;59 (19) :9228-9242.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

Frequently Asked Questions

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