8MDP
8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC50 of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H3] uridine by K562 cells and K15NTD cells[1][2].
Product Specifications
CAS Number
29491-75-6
UNSPSC
12352005
Target
Transmembrane Glycoprotein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8mdp.html
Purity
97.90
Solubility
10 mM in DMSO
Smiles
OCCN(CCO)C1=NC(N2CCCCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCCCC4)C3=N1
Molecular Formula
C28H48N8O4
Molecular Weight
560.73
References & Citations
[1]Lin W, et al. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem. 2007 Aug 9;50 (16) :3906-20.|[2]Lin W, et al. Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2- (N-aminoethyl-N-ethanolamino) -6- (N, N-diethanolamino) pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe. Bioconjug Chem. 2011 Jun 15;22 (6) :1221-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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