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PFM01

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) [1][2].

Product Specifications

CAS Number

1558598-41-6

Product Name Alternative

Stibogluconate (trisodium nonahydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Endonuclease

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pfm01.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 25 mg/mL (ultrasonic)

Smiles

O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S

Molecular Formula

C14H15NO2S2

Molecular Weight

293.40

Precautions

H302, H315, H319

References & Citations

[1]Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53 (1) : 7-18.|[2]Völkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34 (2) : 2812-2820.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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