Nutlin-3

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

548472-68-0

(±) -4-[4,5-Bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one

41116105

Inhibitor

Synthetic

Cancer | Apoptosis | Cancer Growth Inhibitors | p53/mdm2 Inhibitors

>98%

0.025

Yellow solid

Soluble in 100 mM DMSO and Ethanol

C30H30Cl2N4O4

581.9

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Vassilev et al (2004) Science 303: 844.