2'-O-Methylcytidine

2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B) -catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1][2][3].

Product Specifications

CAS Number

[2140-72-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; HCV

Type

Oligonucleotides

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-o-methylcytidine.html

Purity

99.99

Solubility

H2O : 58.33 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO

Molecular Formula

C10H15N3O5

Molecular Weight

257.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278 (14) :11979-84|[2]Hingerty B, et al. The crystal and molecular structure of 2'-O-methylcytidine[J]. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1977, 33 (5) : 1349-1356.|[3]Del Vecchio AM, et al. Small molecule and biologic inhibitors of hepatitis C virus: a symbiotic approach. Mini Rev Med Chem. 2006 Nov;6 (11) :1263-8.