GABAA receptor agent 6

GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 μM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].

Product Specifications

CAS Number

[1808463-81-1]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gabaa-receptor-agent-6.html

Solubility

10 mM in DMSO

Smiles

O=C(C)NC1=CC=CC(C(N2CCC3(CC2)CCNCC3)=O)=C1

Molecular Formula

C18H25N3O2

Molecular Weight

315.41

References & Citations

[1]Bavo F, et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64 (24) :17795-17812.