LDC7559

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages [1].

Product Specifications

CAS Number

[2407782-01-6]

UNSPSC

12352005

Target

Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/LDC7559.html

Concentration

10mM

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC=C1)C2=NN3C(COC(C=C(NC(C)=O)C=C4)=C4C3)=C2

Molecular Formula

C20H19N3O3

Molecular Weight

349.38

References & Citations

[1]Spel L, et al. Gasdermin D opens the way for NETs. Nat Rev Rheumatol. 2018 Dec;14 (12) :690-692.|[2]Sollberger G, et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018 Aug 24;3 (26) . pii: eaar6689.|[3]Ankit Pandeya, et al. Gasdermin D (GSDMD) as a New Target for the Treatment of Infection. Medchemcomm. 2019 Apr 4;10 (5) :660-667.