Recombinant Human PTPN6/SH-PTP1 Protein (His Tag)
Product Specifications
Background
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors.
Abbreviation
PTPN6; SH-PTP1
Synonyms
HCP; Hematopoietic Cell Protein-Tyrosine Phosphatase; PTP-1C; PTP1C; PTPN6; Protein-Tyrosine Phosphatase 1C; Protein-Tyrosine Phosphatase SHP-1; SH-PTP1; Tyrosine-Protein Phosphatase Non-Receptor Type 6
UniProt
P29350
Accession Number
AAH02523.1
Expression System
E.coli
Tag
C-His
Sequence
Lys243-Ile541
Field of Research
Cell Biology, Signal Transduction, Cancer, Developmental Biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
35.4 kDa
Observed Molecular Weight
34 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 2mM β-ME, 1mM EDTA, 1mM DTT, 20% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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