Crisaborole
Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
Product Specifications
CAS Number
906673-24-3
Product Name Alternative
AN-2728; PF-06930164
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/AN-2728.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1
Molecular Formula
C14H10BNO3
Molecular Weight
251.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2129-32.|[2]Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10 (11) :1236-42.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PDE4
Available Sizes
Frequently Asked Questions
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