Curcumin-d6

Curcumin-d6 (Diferuloylmethane-d6) is deuterium labeled Curcumin (HY-N0005) . Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

Product Specifications

CAS Number

[1246833-26-0]

Product Name Alternative

Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Epigenetic Reader Domain; Ferroptosis; Histone Acetyltransferase; Influenza Virus; Isotope-Labeled Compounds; Keap1-Nrf2; Mitophagy

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; Epigenetics; NF-κB; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

O=C(CC(/C=C/C1=CC=C(O)C(OC([2H])([2H])[2H])=C1)=O)/C=C/C2=CC=C(O)C(OC([2H])([2H])[2H])=C2

Molecular Formula

C21H14D6O6

Molecular Weight

374.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915 (13) 004.|[2]Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14 (6) :3449-53.|[3]Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846 (13) 00150-4.|[4]Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68 (6) :431-4.|[5]Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9 (3) :e91303.|[6]Lucas D. Dias, et al. Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy. Journal of Photochemistry and Photobiology C: Photochemistry Reviews. Volume 45, December 2020, 100384.