Prucalopride
Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3].
Product Specifications
CAS Number
179474-81-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H372, H400
Target
5-HT Receptor; Apoptosis; Autophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Prucalopride.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1
Molecular Formula
C18H26ClN3O3
Molecular Weight
367.87
Precautions
H315, H319, H335, H372, H400
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Apolipoprotein D
Available Sizes
Frequently Asked Questions
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