AP39
Product Specifications
UNSPSC Description
AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research[1][2][3].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ap39.html
Purity
95.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C1SSC(C2=CC=C(OC(CCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=C1.[Br-]
Molecular Weight
721.77
References & Citations
[1]Feng-Li Zhao, et al. AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons. Oxid Med Cell Longev. 2016;2016:8360738.|[2]Bartosz Szczesny, et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 2014 Sep 15;41:120-30.|[3]Qutuba G Karwi, et al. AP39, a mitochondria-targeting hydrogen sulfide (H 2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signaling. Br J Pharmacol. 2017 Feb;174(4):287-301.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126124/AP39-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126124/AP39-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1429061-80-2
Available Sizes
Curated Selection
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