PF-00446687 (free base)
PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM[1]. Pf-446687 is brain penetrant[2].
Product Specifications
CAS Number
862281-92-3
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/PF-00446687.html
Purity
99.78
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(N(C[C@@H]1C)C[C@H]([C@@]1(O)C2=CC=CC=C2)C)[C@H](C3)[C@H](C(C=CC(F)=C4)=C4F)CN3C(C)(C)C
Molecular Formula
C28H36F2N2O2
Molecular Weight
470.59
References & Citations
[1]Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53 (8) :3183-97.|[2]Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40 (8) :1856-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MC4R
Available Sizes
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