BX517
Product Specifications
UNSPSC Description
BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
Target Antigen
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BX517.html
Smiles
NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O
Molecular Weight
282.30
References & Citations
[1]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25.|[2]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13842/BX517-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13842/BX517-SDS-MedChemExpress.pdf
CAS Number
850717-64-5
Available Sizes
Curated Selection
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