BX517
BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
Product Specifications
CAS Number
[850717-64-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BX517.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 27 mg/mL
Smiles
NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O
Molecular Formula
C15H14N4O2
Molecular Weight
282.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3819-25.|[2]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3814-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal Thioredoxin-1 Antibody (214) [mFluor Violet 450 SE]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-89460MFV450 0.1 mL
Rabbit Monoclonal Thioredoxin-1 Antibody (214) [mFluor Violet 450 SE]
Ask
View Details 
F4150-28A-ML490 100 µL
FKBP11, NT (FK506-binding Protein 11, Peptidyl-prolyl cis-trans Isomerase FKBP11, PPIase FKBP11, Rotamase, 19kD FK506-binding Protein, 19kD FKBP, FKBP-19, UNQ336/PRO535, FKBP19, FKBP-11) (MaxLight 490) discontinued
Ask
View Details 
I7662-89B-ML750 100 µL
Interferon Regulatory Factor 5 (IRF5, IRF-5, SLEB10) (MaxLight 750) discontinued
Ask
View Details