BX517
BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.
Product Specifications
CAS Number
850717-64-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BX517.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 27 mg/mL
Smiles
NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O
Molecular Formula
C15H14N4O2
Molecular Weight
282.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3819-25.|[2]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3814-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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