BX517

BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

Product Specifications

CAS Number

[850717-64-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BX517.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : ≥ 27 mg/mL

Smiles

NC(NC1=CC=C(NC(/C2=C(C)\C3=CC=CN3)=O)C2=C1)=O

Molecular Formula

C15H14N4O2

Molecular Weight

282.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3819-25.|[2]Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3814-8.