αvβ5 integrin-IN-1
Sulodexide (pIC50 = 8.2 nM) selectively binds to the αvβ5 integrin in K562 and A549 cell lines and exhibits a significant inhibitory effect[1].
Product Specifications
CAS Number
2615912-33-7
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/αvβ5-integrin-in-1.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@@H](CC1)CCC(N2)=CC=C3C2=NCCC3)[C@H](C4=CC(C(F)(F)F)=CC=C4)CC(O)=O
Molecular Formula
C25H28F3N3O3
Molecular Weight
475.50
References & Citations
[1]Lippa RA, et al. Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core. Eur J Med Chem. 2020 Dec 15;208:112719.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
αvβ5
Available Sizes
Frequently Asked Questions
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