RING2/RING1B/RNF2 Rabbit Monoclonal Antibody

Product Specifications

Product Name Alternative

Vinculin; Metavinculin; MV; VCL

UniProt

Q99496

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human RING2 / RING1B / RNF2 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.

Target

E3 ubiquitin-protein ligase RING2

Clonality

Monoclonal

Clone

BCGFEX30

Conjugation

Unconjugated

Field of Research

Epigenetics & Chromatin

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Dilution

WB 1:500-2000 IHC 1:50-200 ICC/IF 1:50-200 FC 1:50

Form

Liquid

Molecular Weight

17 kDa

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

FC, ICC, IF, IHC, WB

Host or Source

Rabbit

Preservative

Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.