Sepin-1

Sepin-1 is a potent separase inhibitor with an IC50 value of 14.8 µM. Sepin-1 inhibits cell proliferation, migration and wound healing. Sepin-1 decreases the expression of FoxM1 protein and mRNA level. Sepin-1 shows anti-tumor activity[1][2].

Product Specifications

CAS Number

[163126-81-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Separase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sepin-1.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[O-][N+]1=C2C(C=C(C=C2)[N+]([O-])=O)=[N+](C1(C)C)[O-]

Molecular Formula

C9H9N3O4

Molecular Weight

223.19

Precautions

H315, H319, H335

References & Citations

[1]Zhang N, et al. Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. J Cancer Sci Ther. 2018;10 (3) :517.|[2]Zhang N, et al. Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. J Biomol Screen. 2014 Jul;19 (6) :878-89.