COX-2-IN-48
COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS[1].
Product Specifications
UNSPSC
12352005
Target
COX; NF-κB; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-48.html
Smiles
FC(C1=C(C2=CC=C(Cl)C=C2)C(C3=CNC4=C3C=CC=C4)C5=C(O1)C=CC(OC)=C5)(F)F
Molecular Formula
C25H17ClF3NO2
Molecular Weight
455.86
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168070/COX-2-IN-48-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168070/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
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