CB-5083

CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM[1].

Product Specifications

CAS Number

[1542705-92-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P97

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CB-5083.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N

Molecular Formula

C24H23N5O2

Molecular Weight

413.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhou HJ, et al. Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083) . J Med Chem. 2015 Dec 24;58 (24) :9480-97.