J 104129 (fumarate)
J 104129 fumarate is a selective and orally active muscarinic M3 antagonist with Ki values of 4.2 nM and 490 nM for M3 and M2, respectively. J 104129 fumarate antagonized ACh-induced bronchoconstriction. J 104129 fumarate has the potential for the research of obstructive airway disease[1].
Product Specifications
CAS Number
257603-40-0
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/j-104129-fumarate.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3.OC(/C=C/C(O)=O)=O
Molecular Formula
C28H40N2O6
Molecular Weight
500.63
References & Citations
[1]Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7 (11) :2555-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR2; mAChR3
Available Sizes
Frequently Asked Questions
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