2-NP

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

Product Specifications

CAS Number

[65182-56-1]

UNSPSC

12352005

Hazard Statement

H302, H318

Target

HSV; JAK; STAT

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/2-np.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=CC=C1C2=NC3=NC=CC=C3C=C2

Molecular Formula

C14H10N2O

Molecular Weight

222.25

Precautions

H302, H318

References & Citations

[1]Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67 (3) :1254-61.|[2]Luo N, et al., Up-regulated Lnc BTU promotes the production of duck plague virus DNA polymerase and inhibits the activation of JAK-STAT pathway to facilitate duck plague virus replication. Poult Sci. 2024 Dec;103 (12) :104238.|[3]Wang Y, et al., A small-molecule enhancer of STAT1 affects herpes simplex keratitis prognosis by mediating plasmacytoid dendritic cells migration through CXCR3/CXCL10. Int Immunopharmacol. 2025 Feb 6;147:113959.