DOTAGA. (SA.FAPi) 2 analogue (TFA)

DOTAGA. (SA.FAPi) 2 analogue TFA is a DOTAGA. (SA.FAPi) 2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA. (SA.FAPi) 2 TFA. DOTAGA. (SA.FAPi) 2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi) [1].

Product Specifications

UNSPSC

12352005

Target

FAP

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dotaga-sa-fapi-2-analogue-tfa.html

Smiles

OC(C(F)(F)F)=O.O=C(O)CN1CCN(C(CCC(NCCNC(C2=O)=C(NCCCCOC3=CC4=C(N=CC=C4C(NCC(N5[C@H](C#N)CC(C5)(F)F)=O)=O)C=C3)C2=O)=O)C(O)=O)CCN(CCN(CC1)CCNCCNC(C6=O)=C(NCCCCOC7=CC8=C(N=CC=C8C(NCC(N9[C@H](C#N)CC(C9)(F)F)=O)=O)C=C7)C6=O)CC(O)=O

Molecular Formula

C75H89F7N18O19

Molecular Weight

1679.61

References & Citations

[1]Tilman Läppchen, et al. Tailoring Fibroblast-Activation Protein Targeting for Theranostics: A Comparative Preclinical Evaluation of the 68Ga- and 177Lu-Labeled Monomeric and Dimeric Fibroblast-Activation Protein Inhibitors DOTA.SA.FAPi and DOTAGA. (SA.FAPi) 2. Molecules. 2024 Jun 28;29 (13) :3093.