Piperonyl butoxide

Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice[1][2][3].

Product Specifications

CAS Number

[51-03-6]

Product Name Alternative

ENT-14250

UNSPSC

12352005

Hazard Statement

H319, H335, H400, H410

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Piperonyl-butoxide.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

CCCC1=C(COCCOCCOCCCC)C=C2OCOC2=C1

Molecular Formula

C19H30O5

Molecular Weight

338.44

Precautions

H319, H335, H400, H410

References & Citations

[1]Muguruma M, et al. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice. Arch Toxicol. 2008 Oct;82 (10) :749-53.|[2]Tanaka T, et al. Effects of piperonyl butoxide on exploratory behaviour in female mice. Toxicol Ind Health. 2019 Apr;35 (4) :314-323.|[3]Takahashi O, et al. Chronic toxicity studies of piperonyl butoxide in CD-1 mice: induction of hepatocellular carcinoma. Toxicology. 1997 Dec 26;124 (2) :95-103.|[4]Jenkins AE, et al. Pharmacokinetic analysis of acute and dietary exposure to piperonyl butoxide in the mouse. Toxicol Rep. 2023 Sep 23;11:310-317.