Seneciphylline

Seneciphylline is an orally effective hepatotoxic inducer. Seneciphylline is metabolized by CYP450 enzymes into active intermediates, which covalently bind to intracellular biomacromolecules such as proteins and DNA to form adducts, which in turn trigger a series of toxic reactions, such as inducing cell apoptosis and damaging mitochondrial function. Seneciphylline can be used in hepatotoxicity research[1][2].

Product Specifications

CAS Number

[480-81-9]

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Cytochrome P450; Glutathione S-transferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/seneciphylline.html

Purity

99.93

Solubility

DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](C)(O)C(C/3)=C)=O)=CC2)C3=C/C

Molecular Formula

C18H23NO5

Molecular Weight

333.38

Precautions

H300+H310+H330

References & Citations

[1]Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12 (3) :271-8.|[2]Wang W, et al. Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis. J Appl Toxicol. 2020 Nov;40 (11) :1534-1544.