PfDHODH-IN-3
PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC50=47 nM) . PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals[1].
Product Specifications
CAS Number
[92872-51-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfdhodh-in-3.html
Smiles
CC1=NC2=NC=NN2C(NC3=CC=C4C=CC=CC4=C3)=C1
Molecular Formula
C16H13N5
Molecular Weight
275.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52 (7) : 1864-1872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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