PfDHODH-IN-3

PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC50=47 nM) . PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals[1].

Product Specifications

CAS Number

[92872-51-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dihydroorotate Dehydrogenase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pfdhodh-in-3.html

Smiles

CC1=NC2=NC=NN2C(NC3=CC=C4C=CC=CC4=C3)=C1

Molecular Formula

C16H13N5

Molecular Weight

275.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52 (7) : 1864-1872.