PfDHODH-IN-3
Product Specifications
UNSPSC Description
PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC50=47 nM). PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals[1].
Target Antigen
Dihydroorotate Dehydrogenase; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfdhodh-in-3.html
Smiles
CC1=NC2=NC=NN2C(NC3=CC=C4C=CC=CC4=C3)=C1
Molecular Weight
275.31
References & Citations
[1]Gujjar R, et al. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice[J]. Journal of medicinal chemistry, 2009, 52(7): 1864-1872.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116713/PfDHODH-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116713/
Clinical Information
No Development Reported
CAS Number
92872-51-0
Curated Selection
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