Halobetasol propionate

Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis[1][2].

Product Specifications

CAS Number

[66852-54-8]

Product Name Alternative

BMY-30056; CGP-14458; Ulobetasol propionate

UNSPSC

12352211

Hazard Statement

H301-H311-H331-H341

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Halobetasol-propionate.html

Purity

99.88

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@]12[C@](C(CCl)=O)(OC(CC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Molecular Formula

C25H31ClF2O5

Molecular Weight

484.96

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Kundu-Raychaudhuri S, et al. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014 Dec;55:63-72. |[2]Yawalkar S, et al. Dermatopharmacologic investigations of halobetasol propionate in comparison with clobetasol 17-propionate. J Am Acad Dermatol. 1991 Dec;25 (6 Pt 2) :1137-44.