GSK1790627
GSK1790627 is the N-deacetylated metabolite of Trametinib. Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis[1].
Product Specifications
CAS Number
871701-87-0
UNSPSC
12352005
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk1790627.html
Purity
99.08
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C2=CC=CC(N)=C2)C(C(C(N1C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O
Molecular Formula
C24H21FIN5O3
Molecular Weight
573.36
References & Citations
[1]Ho MY, et al. Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers. Xenobiotica. 2014 Apr;44 (4) :352-68.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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