Phytosphingosine
Product Specifications
UNSPSC Description
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].
Target Antigen
Apoptosis; Endogenous Metabolite; Free Fatty Acid Receptor; Fungal
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phytosphingosine.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
Molecular Weight
317.51
References & Citations
[1]1. Pavicic T, Wollenweber U, Farwick M, et al. Anti‐microbial and‐inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris[J]. International journal of cosmetic science, 2007, 29(3): 181-190.|[2]Cai Q, et al. Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo. Chem Biol Interact. 2024 Jan 5;387:110795.|[3]Glenz R, et al. The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens. Sci Rep. 2022 Jan 20;12(1):1081. |[4]Nagasawa T, et al. Phytosphingosine is a novel activator of GPR120. J Biochem. 2018 Jul 1;164(1):27-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W011303/Phytosphingosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W011303/Phytosphingosine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
554-62-1
Available Sizes
Curated Selection
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