RX-3117
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1) . RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis[1][2][3].
Product Specifications
CAS Number
865838-26-2
Product Name Alternative
TV-1360; Fluorocyclopentenylcytosine
UNSPSC
12352005
Target
Apoptosis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RX-3117.html
Purity
99.25
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1N([C@@H]2C(F)=C(CO)[C@@H](O)[C@H]2O)C=CC(N)=N1
Molecular Formula
C10H12FN3O4
Molecular Weight
257.22
References & Citations
[1]Sarkisjan D, et al. The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. PLoS One. 2016 Sep 9;11 (9) :e0162901.|[2]Balboni B, et al. RX-3117 (fluorocyclopentenyl cytosine) : a novel specific antimetabolite for selective cancer treatment. Expert Opin Investig Drugs. 2019 Apr;28 (4) :311-322.|[3]Fahy J, et al. DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat. 2012 Dec;22 (12) :1427-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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