RX-3117

RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1) . RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis[1][2][3].

Product Specifications

CAS Number

[865838-26-2]

Product Name Alternative

TV-1360; Fluorocyclopentenylcytosine

UNSPSC

12352005

Target

Apoptosis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RX-3117.html

Purity

99.25

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1N([C@@H]2C(F)=C(CO)[C@@H](O)[C@H]2O)C=CC(N)=N1

Molecular Formula

C10H12FN3O4

Molecular Weight

257.22

References & Citations

[1]Sarkisjan D, et al. The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. PLoS One. 2016 Sep 9;11 (9) :e0162901.|[2]Balboni B, et al. RX-3117 (fluorocyclopentenyl cytosine) : a novel specific antimetabolite for selective cancer treatment. Expert Opin Investig Drugs. 2019 Apr;28 (4) :311-322.|[3]Fahy J, et al. DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat. 2012 Dec;22 (12) :1427-42.