8RK64

8RK64, a chemical probe, is a covalent UCHL1 inhibitor (IC50: 0.32 μM) [1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2705841-52-5]

UNSPSC

12352005

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8rk64.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CN1CC[C@@H](C1)C(NC2=NC3=C(S2)CN(CC3)C(CN=[N+]=[N-])=O)=O

Molecular Formula

C14H16N8O2S

Molecular Weight

360.39

References & Citations

[1]Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142 (39) :16825-16841.