Calpeptin
Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets[1]. Calpeptin is also an inhibitor of cathepsin K[2].
Product Specifications
CAS Number
117591-20-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Cathepsin; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Calpeptin.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C
Molecular Formula
C20H30N2O4
Molecular Weight
362.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Tsujinaka T, et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin) . Biochem Biophys Res Commun. 1988 Jun 30;153 (3) :1201-8.|[2]Catalano JG, et al. Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2004 Feb 9;14 (3) :719-22.|[3]Tabata C, et al. The calpain inhibitor calpeptin prevents pulmonary fibrosis in mice. Clin Exp Immunol. 2010 Dec;162 (3) :560-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K
Available Sizes
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