Calpeptin

Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets[1]. Calpeptin is also an inhibitor of cathepsin K[2].

Product Specifications

CAS Number

[117591-20-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Cathepsin; Proteasome

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Calpeptin.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C

Molecular Formula

C20H30N2O4

Molecular Weight

362.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Tsujinaka T, et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin) . Biochem Biophys Res Commun. 1988 Jun 30;153 (3) :1201-8.|[2]Catalano JG, et al. Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2004 Feb 9;14 (3) :719-22.|[3]Tabata C, et al. The calpain inhibitor calpeptin prevents pulmonary fibrosis in mice. Clin Exp Immunol. 2010 Dec;162 (3) :560-7.