N- (p-Coumaroyl) Serotonin

N- (p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2 and caspase-8 with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N- (p-Coumaroyl) Serotonin inhibits glioblastoma cells (U251MG, T98G) with IC50 of 48-81 μM, while the IC50 for normal fibroblasts is 181-197 μM. N- (p-Coumaroyl) Serotonin inhibits PDGF signaling (reducing receptor phosphorylation), blocks Ca2+ influx, and induces apoptosis (activating caspase-8) . N- (p-Coumaroyl) Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma[1][2][3].

Product Specifications

CAS Number

[68573-24-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Caspase; ERK; PDGFR

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-p-coumaroyl-serotonin.html

Purity

99.03

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCCC1=CNC2=C1C=C(O)C=C2)/C=C/C3=CC=C(O)C=C3

Molecular Formula

C19H18N2O3

Molecular Weight

322.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Lazari D, et al. N- (p-coumaroyl) serotonin inhibits glioblastoma cells growth through triggering S-phase arrest and apoptosis. J Neurooncol. 2017 May;132 (3) :373-381.|[2]Takimoto T, et al. Effect of N- (p-coumaroyl) serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells. Mol Nutr Food Res. 2011 Oct;55 (10) :1561-71.|[3]Shin-ichiro Katsuda, et al. Safflower seed polyphenols (N- (p-coumaroyl) serotonin and N-feruloylserotonin) ameliorate atherosclerosis and distensibility of the aortic wall in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits.Hypertens Res.