Monomethyl auristatin E intermediate-1

Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162) . Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[120205-48-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-1.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC[C@H](C)[C@H](NC)[C@H](OC)CC(OC(C)(C)C)=O.Cl

Molecular Formula

C14H30ClNO3

Molecular Weight

295.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.