Guanosine triphosphate-15N5 (dilithium)

Guanosine triphosphate-15N5 (GTP-15N5) dilithium is 15N labeled Guanosine triphosphate (HY-113225) . Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.

Product Specifications

Product Name Alternative

GTP-15N5 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/guanosine-triphosphate-15n5-dilithium.html

Concentration

100 mM in 92.59 μL Tris HCl/H2O buffer pH=7.5

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Li])OP(OP(OC[C@H]1O[C@@H]([15N]2C([15N]=C([15NH2])[15NH]C3=O)=C3[15N]=C2)[C@H](O)[C@@H]1O)(O)=O)(O[Li])=O

Molecular Formula

C10H14Li2 15N5O14P3

Molecular Weight

540.01

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.