Gboxin
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1].
Product Specifications
CAS Number
[2101315-36-8]
UNSPSC
12352005
Target
ATP Synthase; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Gboxin.html
Concentration
10mM
Purity
98.23
Solubility
DMSO : 32.5 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)CN2C(CC)=[N+](C)C3=CC=CC=C23.[Cl-]
Molecular Formula
C22H33ClN2O2
Molecular Weight
392.96
References & Citations
[1]Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567 (7748) :341-346.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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