Dehydrodiisoeugenol

Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions[1]. Dehydrodiisoeugenol inhibits LPS- stimulated NF-κB activation and cyclooxygenase (COX) -2 gene expression in murine macrophages[2].

Product Specifications

CAS Number

[2680-81-1]

UNSPSC

12352005

Hazard Statement

H302+H312, H315, H317, H319

Target

Bacterial; COX; NF-κB

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dehydrodiisoeugenol.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C2OC3=C(OC)C=C(/C=C/C)C=C3C2C)C=C1OC

Molecular Formula

C20H22O4

Molecular Weight

326.39

Precautions

H302+H312, H315, H317, H319

References & Citations

[1]Murakami Y, et al. Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. Arch Biochem Biophys. 2005 Feb 15;434 (2) :326-32.|[2]Lv QQ, et al. Metabolic profiling of dehydrodiisoeugenol using xenobiotic metabolomics. J Pharm Biomed Anal. 2017 Oct 25;145:725-733.