LY2023-001
LY2023-001 is a potent G2019S LRRK2 inhibitor with an IC50 of 12.9 nM. LY2023-001 formed stable hydrogen bonds with Glu1948, and Ala1950 in the G2019S LRRK2 protein[1].
Product Specifications
CAS Number
327031-30-1
UNSPSC
12352211
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly2023-001.html
Smiles
COC1=C(O)C(OC)=CC(/C=N/NC2=NN=C(C(C=C(C)C=C3)=C3N4)C4=N2)=C1
Molecular Formula
C19H18N6O3
Molecular Weight
378.38
References & Citations
[1]Shuoyan Tan, et al. Identification of novel LRRK2 inhibitors by structure-based virtual screening and alchemical free energy calculation. Phys Chem Chem Phys. 2024 Jul 24;26 (29) :19775-19786.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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