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LY2023-001

LY2023-001 is a potent G2019S LRRK2 inhibitor with an IC50 of 12.9 nM. LY2023-001 formed stable hydrogen bonds with Glu1948, and Ala1950 in the G2019S LRRK2 protein[1].

Product Specifications

CAS Number

327031-30-1

UNSPSC

12352211

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly2023-001.html

Smiles

COC1=C(O)C(OC)=CC(/C=N/NC2=NN=C(C(C=C(C)C=C3)=C3N4)C4=N2)=C1

Molecular Formula

C19H18N6O3

Molecular Weight

378.38

References & Citations

[1]Shuoyan Tan, et al. Identification of novel LRRK2 inhibitors by structure-based virtual screening and alchemical free energy calculation. Phys Chem Chem Phys. 2024 Jul 24;26 (29) :19775-19786.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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